Chimeric antigen receptors (CARs) are designed and engineered in a modular fashion that typically consists of an extracellular target-binding domain, a hinge region, a transmembrane domain that anchors the CAR to the cell membrane, and one or more intracellular domains that transmit activation signals. Depending on the number of costimulatory domains, Engineered CARs can be classified into first (CD3ζ only), second (one costimulatory domain + CD3ζ), or third generation CARs (more than one costimulatory domain + CD3ζ).
Oak Biosciences’ chimeric antigen receptors (CARs) design and engineering services focus on modification of αβ-T cells with CARs. Moreover, we also have developed strategies to introduce CARs into other immune cell types, including γδ-T cells, natural killer cells, natural killer T cells, and macrophages. Our CAR design will to be tailored to each cell type you requested.
Oak Biosciences provides the following CAR engineering Services
1. CAR Design and Optimization
2. CAR-T cell generation via viral vectors
3. CAR-T cell generation via non-viral vectors
4. T-cell receptor (TCR) engineered cells generation
5. CAR NK cell generation
For other CAR related services, please fill the form for a custom inquiry!